![]() Boulouis G, Etten ES, Charidimou A, Auriel E, Morotti A, Pasi M, et al. Magnetic resonance imaging in cerebral small vessel disease and its use as a surrogate disease marker. Magnetic resonance imaging (MRI) is often used for diagnosis of cerebral small vessel disease 6 6. These correlations are especially notable for cognitive disorder and dementia. Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease. de Laat KF, Tuladhar AM, van Norden AG, Norris DG, Zwiers MP, de Leeuw FE. Small vessel disease and Alzheimer's dementia: pathological considerations. Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. van der Flier WM, van Straaten EC, Barkhof F, Verdelho A, Madureira S, Pantoni L, et al. Cognitive impairment and functional outcome after stroke associated with small vessel disease. Mok VC, Wong A, Lam WW, Fan YH, Tang WK, Kwok T, et al. Cerebral small vessel disease has been found to be correlated with diseases including stroke 2 2. Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study. Conijn MM, Kloppenborg RP, Algra A, Mali WP, Kappelle LJ, Vincken KL, et al. A ultrassonografia TCD pode orientar a ressonância magnética seletiva para detecção da WML.ĭoenças de pequenos vasos cerebrais ultrassonografia Doppler transcranianoĬerebral small vessel disease is one of the causes of ischemic stroke 1 1. O PI da MCA na ultrassonografia do TCD está significativamente relacionado à WML grave. Os valores preditivos positivos e negativos foram de 35,4% e 86,6%, respectivamente. A sensibilidade e especificidade foram de 63,0% e 72,0%, respectivamente. A análise dos parâmetros ultrassonográficos do TCD mostrou que, quando o ponto de corte do IP do MCA foi 1,04, ele pôde identificar à WML grave. A análise de regressão logística multivariada mostrou que apenas a idade (razão de chances: 1,21 IC95%: 1,10-1,36 P <0,01) e o PI da MCA (razão de dominância: 1,13 IC 95%: 1,06-1,80 P = 0,02) estiveram significativamente relacionados a WML grave. Resultados:Ī análise univariada mostrou que, a idade, a velocidade média de fluxo (MFV) da artéria média cerebral (MCA) esquerda, a MFV da MCA direita e o índice de pulsatilidade (PI) médio estiveram significativamente relacionados à WML grave (P <0,05). As relações das características clínicas e os parâmetros ultrassonográficos do TCD com lesão grave de substância branca (WML) no desempenho da RM foram investigados por análise univariada e análise multivariada. Ultrassonografia de TCD e ressonância magnética (RM) foram realizadas em 184 idosos portadores de SVD cerebral. Investigar o valor preditivo do ultrassom de Doppler transcraniano (TCD) para doença de pequenos vasos (SVD) em pacientes idosos. The MCA pulsatility index in TCD ultrasound is significantly correlated with severe WMLs and TCD ultrasound can guide selective MRI for the detection of WMLs.Ĭerebral small vessel disease ultrasonography, transcranial doppler The positive and negative predictive values were 35.4% and 86.6%, respectively. The sensitivity and specificity were 63.0% and 72.0%, respectively. The analysis of TCD ultrasound parameters showed that when the cut-off for MCA pulsatility index was 1.04, it could identify severe WMLs. The multivariate logistic regression analysis showed that only age (odds ratio: 1.21 95%CI: 1.10–1.36 p < 0.01) and MCA pulsatility index (dominance ratio: 1.13 95%CI: 1.06–1.80 p = 0.02) were significantly correlated with severe WMLs. The univariate analysis showed that age, left middle cerebral artery (MCA) mean flow velocity, right MCA mean flow velocity and mean MCA pulsatility index were significantly correlated with severe WMLs (p < 0.05). The relationship of clinical characteristics and TCD ultrasound parameters with severe white matter lesions (WMLs) in MRI were investigated by univariate analysis and multivariate analysis. ![]() Transcranial Doppler ultrasound and magnetic resonance imaging (MRI) were performed on 184 elderly patients with cerebral small vessel disease. ![]() To investigate the predictive value of transcranial Doppler (TCD) ultrasound for cerebral small vessel disease in elderly patients.
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